Nr.

Correlation

Explanation

1

Spatial correlation between location of hypertrophic adipocytes and degree of lipolytic resistance of fat depots.

Lipolytically more resistant sWAT in gluteo-femoral depots consists of bigger adipocytes comparing to lipolytically less resistant fat depots in other body areas [27] .

2

Spatial correlation between location of hypertrophic adipocytes and HA accumulation in fat tissue.

There is a significantly higher accumulation of specific HA in hypertrophic fat tissue compared to normal fat tissue [8] [9] .

3

Spatial correlation between HA content and fibrosis in hypertrophic fat tissue.

Fibrosis is considered to be a hallmark of hypertrophic fat tissue [10] .

4

Spatial correlation between HA content and induction of collagen types I and III in the tissue.

This effect was clearly demonstrated e.g. by lung fibrosis, and it may be of primary significance for hypertrophic and keloid scarring [28] .

5

Possible correlation between accumulation of HA of some molecular weight with production of collagen types IV and VI.

Such correlation looks to be very reasonable but it had not been investigated until now. If HAs really work as informational molecules [29] , the molecular weight of HA stimulating production of collagen types IV and VI has to be different from that which induces fibrillar collagen types I and III.

6

Possible correlation between perivascular fibrosis and disturbances of micro-circulation in hypertrophic fat tissue.

Although perivascular fibrosis in a hypertrophic fat tissue is well known [30] and can lead to restriction of vasodilation, its spatial correlation with the disturbance of micro-circulation in such tissue still has to be investigated.

7

Correlation between direct lipolytic effect of glucocorticoids (GC) and their ability to suppress the HA synthesis.

GCs can quickly and effectively suppress the HA synthesis, which can be the main reason for their atrophic action [26] . On the other hand, GCs can directly stimulate lipolysis [19] . If these two effects are connected to each other, the lipolytic effect of GCs can be explained through removal of HA from adipocytes’ surfaces, which can temporally restore the lipolytic activity of these cells.

8

Correlation between local depletion of HA through application of HYD and sWAT volume reduction.

Chronic application of HYD leads to reduction of adipocytes’ volumes without excessive death of these cells [9] .